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MCB+102+F10 lecture 05

MCB+102+F10 lecture 05 - Four Levels of Structure in...

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Four Levels of Structure in Proteins Primary Structure Secondary Structure Tertiary Structure Quaternary Structure
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Primary Structure of Bovine Pancreatic RNAse A
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Amino Acid Sequence Determines Protein Structure Rapid Dilution Renatured Slow Dialysis (catalytically active) The Anfinsen Experiment urea
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Bond Bond Length (A˚) Bond Strength (Dissoc. Energy) (kJ/mol) C—C 1.54 356 C—N 1.50 292 C—N 1.32 615 S—S 2.06 214 C—O 1.24 730 Importance of covalent bonds (4.184 kJ = 1 kcal) Thermal motion (~2 kJ / ˚C) causes bonds to stretch twist bend So, even at 100˚C, not enough energy to break any covalent bond in a protein
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: Properties of the Peptide Bond Tautomerization (resonance of the lone pair from the amide nitrogen to the carbonyl oxygen allows for greater electron delocalization) gives every peptide bond: (a) a dipole moment (due to the charge separation) (b) planarity (due to the partial double bond character of the amide C—N linkage)
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MCB+102+F10 lecture 05 - Four Levels of Structure in...

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