MCB+102+F10 lecture 06 - Primary structure dictates...

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Unformatted text preview: Primary structure dictates secondary and tertiary structure Folded (Native) State Newly-made (Nascent) State of Protein 1 of Protein 2 n n-1 n-2 n n-1 n-2 N C Secondary H 3 OO- Adopt Condense HOW does primary structure determine the 3D fold? : Properties of the Peptide Bond Tautomerization (resonance of the lone pair from the amide nitrogen to the carbonyl oxygen allows for greater electron delocalization) gives every peptide bond: (a) a dipole moment (due to the charge separation) (b) planarity (due to the partial double bond character of the amide CN linkage) Steric constraints contribute to determining protein structure Steric clash X-Pro bonds are the exception Polypeptide backbone is a series of planes joined by swivel joints | H Definition of ("phi") and ("psi") angles A residue in the polypeptide chain Allowed conformational space: The Ramachandran Plot -helix: One of the most energetically and sterically favorable of the allowed conformations - - 3.6 residues per turn -helix: R side chains on exterior minimizes their steric clash "Face" Helical Wheel Plot "Face" 1 5 9...
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MCB+102+F10 lecture 06 - Primary structure dictates...

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