{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

MCB+102+F10 lecture 06

MCB+102+F10 lecture 06 - Primary structure dictates...

Info iconThis preview shows pages 1–12. Sign up to view the full content.

View Full Document Right Arrow Icon
Primary structure dictates secondary and tertiary structure Folded (Native) State Newly-made (Nascent) State of Protein 1 of Protein 2 n n -1 n -2 n n -1 n -2
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
N C Secondary H 3 OO - Adopt Condense HOW does primary structure determine the 3D fold?
Background image of page 2
: Properties of the Peptide Bond Tautomerization (resonance of the lone pair from the amide nitrogen to the carbonyl oxygen allows for greater electron delocalization) gives every peptide bond: (a) a dipole moment (due to the charge separation) (b) planarity (due to the partial double bond character of the amide C—N linkage)
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Steric constraints contribute to determining protein structure Steric clash —X-Pro— bonds are the exception
Background image of page 4
Polypeptide backbone is a series of planes joined by swivel joints
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
| H Definition of φ ("phi") and ψ ("psi") angles A residue in the polypeptide chain
Background image of page 6
Allowed conformational space: The Ramachandran Plot
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
α -helix: One of the most energetically and sterically favorable of the allowed conformations α - α -
Background image of page 8
3.6 residues per turn α -helix: R side chains on exterior minimizes their steric clash "Face"
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Helical Wheel Plot "Face" 1 5 9
Background image of page 10
Background image of page 11

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Image of page 12
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}