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MCB+102+F10 lecture 08

MCB+102+F10 lecture 08 - Adaptive Immunity MHC complexes...

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MHC complexes present a sampling of whole proteome complexity (our own proteins AND invading pathogen proteins) by displaying processed peptides on the cell surface. T cell surface receptors bind MHC complexes and trigger a defensive immune response; early in development, we eliminate molecules that recognize our own proteins (we gain “tolerance”) or otherwise show autoimmune disease (we react in a hostile manner against ourselves). B cells produce and secrete antibodies. Macrophages digest antibody-coated particles. Adaptive Immunity
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Class I molecules are broadly expressed. Class II molecules are expressed at sites of inflammation.
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This MHC I complex is shown with its bound ~9 aa peptide that, when recognized by a T cell, is the antigen ( anti body gen erator) for an immune response. MHC is Major Histocompatibility Complex. MHC molecules in one person versus another tend to select a different set of peptides for presentation, because the surface groove ‘fits’ peptides slightly differently. Transplant
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