Bio218 midterm.VersionC

Bio218 midterm.VersionC - B io218 Mid- term Examination 1 B...

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Bio218Mid-term Examination BIO 218 MID-TERM EXAMINATION 25% of FINAL GRADE CHPS 9, 10, 11, 12 FORMAT: SHORT ANSWER MULTIPLE CHOICE USE THE ATTACHED ANSWER SHEET VERSION C 1
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Bio218Mid-term Examination 1. Which is a true difference between DNA and RNA? a. The 5’ carbon on the base of RNA has a phosphate group and the 2’ carbon on the base of DNA had a hydroxyl group b. DNA is largely single stranded and RNA is largely double stranded c.The 2’ carbon on the pentose sugar of RNA has a hydroxyl group and the 2’ carbon on the pentose sugar of DNA had a hydrogen d. The 2’ carbon on the base of DNA has a hydroxyl group and the 2’ carbon on the base of RNA had a hydrogen e. The 2’ carbon on the pentose sugar of DNA has a hydroxyl group and the 2’ carbon on the base of RNA had a hydrogen 2. What are Chargaff’s ratios? 3. In the Watson-Crick double-helix model of DNA, how are the nitrogenous bases oriented relative to the sugar phosphate backbone. 4. Complementary bases in DNA bond to each other via: a. Long distance weak interactions b. Strong ionic interactions c. Weak hydrogen bonds d. Weak covalent interactions e. Strong hydrogen bonds 5. It is thought that a human telomere a. Has a 5’ double-stranded invasion of a repeating downstream t-loop sequence b. Has a 3’ single-stranded overhang approximately 1.25 to 2.75 X 10 6 bp in length 2
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Bio218Mid-term Examination c. Has a TRF-1 complex coating the single-strand displaced by the invading 3’ overhang at the end of the t-loop d. Has POT-1 coating the single-strand displaced by the invading 3’ overhang at the end of the t-loop e. Has an AT rich 3’ overhang that invades a repeating upstream sequence of the t-loop 6. Which of the following is true about the proteins in the nucleosome core? a. They consist of two molecules each of H1, H2a, H2b, and H4 b. Segments of DNA in the nucleosome core are protected from endonuclease cleavage by these proteins c. They consist of two molecules each of H2a, H2b, H3, and H4 d. They are rich in acidic amino acids e. b. and c. are true 7. The rule that purines and pyrimidines interact with each other on opposite strands of DNA results in the DNA double-helix having a constant . Identify the following structures 8. 9. 10. 3
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11. 12. 13. 14. 15. 16. Which one of the following sequences is the complementary strand to this DNA sequence? 5’-CGTGCATCAT-3’ a. 3’-CGTGCATCAT-5’ b. 5’-ATGATGCACG-3’ c. 3’-GCTCGTAGTA-5’ d. 5’-ATGTACCAGG-3’ e. 3’-GCTCGATGAT-5’ 17. Name the three phases of replication. 18.How many hydrogen bonds are in the following segment of DNA?
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This note was uploaded on 03/09/2011 for the course BIO 218 taught by Professor Castronuevo during the Winter '08 term at Drexel.

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Bio218 midterm.VersionC - B io218 Mid- term Examination 1 B...

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