Homework#2 MCB410 Spring 2011

Homework#2 MCB410 Spring 2011 - NAME_lien lai 1(3 pts...

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NAME: __lien lai_______________________________ 1. (3 pts) Whenever vesicles fuse with target membranes their v-SNAREs are transferred to the target membrane t-SNAREs. For an actively secreting cell this could eventually lead to an accumulation of v-SNAREs in the plasma membrane. How might the cell avoid this accumulation? After fusion, v- snares are inactive with t-snares. NSF will pull the v snare and t-snare apart, v -snare is kept inactive by binding to inhibitory proteins. Or through active retrieval pathways: v-snares are placed into vesicles so they can be deliver back to the original donor membrane. 2. (2 pts) All of the glycoproteins in the ER have sugars facing the luminal side. For the proteins that will become part of the plasma membrane, what direction will the sugars face on the plasma membrane? The sugar will be facing the outside of the cell. 3.(10 pts) In cell extracts, you can observe clathrin-coated vesicles bud from isolated eukaryotic plasma membrane fragments when adaptins, clathrin, and dynamin-GTP are added. What would you expect to occur if the following modifications are made to the
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