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Handout3 - TA Clarissa Chan Section Wed 12-12:50p Coffee...

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TA: Clarissa Chan OH: Tues 10-11a Section: Wed 12-12:50p Mandeville Coffee Cart Handout #3 (through 1/24) G Proteins (continued) 3 types o Gα Stimulating activates ________________ which hydrolyzes ATP to ADP + Pi _______ is generated protein kinase A then phosphorylates proteins activity is either increased or decreased _______________________ o Gα Inhibitory inactivates _____________ cAMP activity is decreased Protein kinase A in inactivated activity is either increased or decreased o Gα Q phospholipase Cβ is activated which cleaves bonds PIP 2 in the phospholipid bilayer is broken down to result in _____ and ______ DAG remains in the membrane because it is a fatty acid. Leads to an increase in protein kinase C which is responsible for _________________membrane proteins IP 3 is a ligand that binds to ion channel receptors in the endoplasmic reticulum resulting in the release of Calcium from intracellular stores. Ultimately results in an increase of ________________ and an increase in secretion of Calcium vesicles. An example of a second messenger used in G protein receptor pathways is phosphodiesterases which hydrolyze ester bonds causing cAMP _______ and therefore inactivating Protein Kinase A.
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