Handout6 - TA Clarissa Chan Section Wed 12-12:50p Coffee...

Info iconThis preview shows pages 1–3. Sign up to view the full content.

View Full Document Right Arrow Icon
TA: Clarissa Chan OH: Tues 10-11a Section: Wed 12-12:50p Mandeville Coffee Cart Handout #6 (through 2/14) Thyroid Hormone o Made from____________ and _____________ o ______ is the most potent but _______ is more abundant o Lipid soluble, therefore receptors are lipid soluble, making receptors intracellular, and can therefore give rise to changes in gene expression o Pathway: Hypothalamus (_____) Anterior Pituitary (______) Thyroid gland (____________) T3 to systemic metabolic effects Negative feedback: T3,T4 inhibit __________________ o Effects: Increased ________________ Increased _________________ Increased Na/K ATPase activity and ion leaks Increased uncoupling of oxidative phosphorylation o Problems with Secretion Primary problem with secretion: Thyroid gland. Symptoms will be a normal amounts of _______________ but no _____________ Secondary problem: Anterior pituitary. No TSH or T4 or T3 will be released. TRH will be present o Goiter: _____________________________ Can result from hyperthyroidism or hypothyroidism Results in an enlarged Thyroid in hopes of absorbing more iodine. The US has countered this problem by adding Iodine to table salt
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
o Hyperthyroidism ________________________________ Graves Disease: autoimmune disease that causes antibodies to stimulate thyroid TSH receptors to over secrete TSH and grow Hypothalamus: ↓TRH because of inhibition from increased T3 and T4 Anterior Pituitary: ↓TSH for the same reason High T3 and T4 Signs: Exophthalamus (bulging eyes), weight loss, increased heat sensitivity.
Background image of page 2
Image of page 3
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 03/10/2011 for the course BIPN 100 taught by Professor French during the Winter '07 term at UCSD.

Page1 / 6

Handout6 - TA Clarissa Chan Section Wed 12-12:50p Coffee...

This preview shows document pages 1 - 3. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online