Handout6TA - TA: Clarissa Chan Section: Wed 12-12:50p...

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TA: Clarissa Chan OH: Tues 10-11a Section: Wed 12-12:50p Mandeville Coffee Cart Handout #6 (through 2/14) Thyroid Hormone o Made from tyrosine and iodine o T3 is the most potent but T4 is more abundant o Lipid soluble, therefore receptors are lipid soluble, making receptors intracellular, and can therefore give rise to changes in gene expression o Pathway: Hypothalamus ( TRH ) Anterior Pituitary ( TSH ) Thyroid gland ( ) T3 to systemic metabolic effects Negative feedback: T3,T4 inhibit TRH and TSH secretion o Effects: Increased metabolism Increased heat generation Increased Na/K ATPase activity and ion leaks Increased uncoupling of oxidative phosphorylation o Problems with Secretion Primary problem with secretion: Thyroid gland. Symptoms will be a normal amounts of TRH and TSH but no T3 or T4 Secondary problem: Anterior pituitary. No TSH or T4 or T3 will be released. TRH will be present o Goiter: due to a deficiency in Iodine Can result from hyperthyroidism or hypothyroidism Results in an enlarged Thyroid in hopes of absorbing more iodine. The US has countered this problem by adding Iodine to table salt o Hyperthyroidism (high levels of thyroid hormone)
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Graves Disease: autoimmune disease that causes antibodies to stimulate thyroid TSH receptors to over secrete TSH and grow Hypothalamus: ↓TRH because of inhibition from increased T3 and T4 Anterior Pituitary: ↓TSH for the same reason High T3 and T4 Signs: Exophthalamus (bulging eyes), weight loss, increased heat sensitivity. o
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This note was uploaded on 03/10/2011 for the course BIPN 100 taught by Professor French during the Winter '07 term at UCSD.

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Handout6TA - TA: Clarissa Chan Section: Wed 12-12:50p...

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