BIS 101 Notes 1-26-11

BIS 101 Notes 1-26-11 - B IS 101 Lecture 7 Chapter 6 I...

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BIS 101 1/26/11 Lecture 7 Chapter 6 I. Genes in Pathways a. Archibald Garrod, discoverer of inborn errors of metabolism b. alkaptonuria, discovered one of first human gene problems c. Isolation of an arginine auxotrophic mutation, i. Lead to a famous statement in genetics: 1. Beadle Tatum experiment: “one gene, one enzyme” 2. That each gene produces an enzyme, in order to get from 1 end of the pathway to the end, you have to go through multiple steps 3. The pathway is potentially blockable by mutation of any one step ii. Beadle Tatum experiment: mutagenizing haploid fungi with x-rays 1. (Fig 6-11) iii. Complete medium: has everything needed to reproduce and survive, everything should grow, lots of added vitamins, amino acids, etc iv. Minimal medium: nutrients to grow / reproduce, only wild types will grow 1. No growth on minimal medium identifies nutritional mutant 2. To find what is mutant, make a minimal and complete control, then make a minimal + amino acids, and a minimal + vitamins, and see where it would survive, to see what the organism potentially might be missing v. So we find that it survived in the minimal + amino acids 1. But what amino acid? 2.
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BIS 101 Notes 1-26-11 - B IS 101 Lecture 7 Chapter 6 I...

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