19.PI.Biodegradation.11

19.PI.Biodegradation.11 - Biodegradation Reactions –...

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Unformatted text preview: Biodegradation Reactions – Phase I Introduction to Biodegradation Reactions Cytochrome P450 Monooxygenases Examples of P450-Catalyzed Reactions Hydrolases Summary and Conclusions I. Introduction to Biodegradation Reactions Oxidation – loss of electrons or gain of oxygen bonds Reduction – gain of electrons or loss of oxygen bonds Hydrolysis – reaction with water (a nucleophile) Role of Biodegradation in Homeostasis Homeostasis – an organism’s ability to maintain stable internal conditions when the outside world is continuously changing Hepatic biodegradation – maintains homeostasis during exposure to small foreign molecules (pesticides, drugs, etc.) Immune system – maintains homeostasis during exposure to large foreign molecules (proteins, etc.) or small organisms (bacteria, viruses) General Strategy and Benefits Reactions often directly detoxify a chemical Reactions usually increase water solubility of a chemical *picture is the hepatic cell (liver cell) II. Cytochrome P450 II....
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This note was uploaded on 03/10/2011 for the course ETX 102A taught by Professor Ronaldtjeerdema during the Winter '10 term at UC Davis.

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19.PI.Biodegradation.11 - Biodegradation Reactions –...

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