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19.PI.Biodegradation.11

19.PI.Biodegradation.11 - Biodegradation Reactions Phase I...

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Biodegradation Reactions – Phase I Introduction to Biodegradation Reactions Cytochrome P450 Monooxygenases Examples of P450-Catalyzed Reactions Hydrolases Summary and Conclusions
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I. Introduction to Biodegradation Reactions Oxidation – loss of electrons or gain of oxygen bonds Reduction – gain of electrons or loss of oxygen bonds Hydrolysis – reaction with water (a nucleophile)
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Role of Biodegradation in Homeostasis Homeostasis – an organism’s ability to maintain stable internal conditions when the outside world is continuously changing Hepatic biodegradation – maintains homeostasis during exposure to small foreign molecules (pesticides, drugs, etc.) Immune system – maintains homeostasis during exposure to large foreign molecules (proteins, etc.) or small organisms (bacteria, viruses)
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General Strategy and Benefits Reactions often directly detoxify a chemical Reactions usually increase water solubility of a chemical *picture is the hepatic cell (liver cell)
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II. Cytochrome P450
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