7.012_Section_5-_solution_key_-2010

# 7.012_Section_5-_solution_key_-2010 - Solution key 7.012...

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1 Solution key - 7.012 Recitation 5 - 2010 Questions: 1. In the box below, write the most likely mode of inheritance of the following pedigree? Given each consistent mode of inheritance, if the couple in question decides to have a child, what is the probability of that child being affected? (Note: Use the uppercase or lowercase A to represent the alleles for the dominant and recessive traits). If Individual#5 has the disease than both his parents are carriers i.e. #1 and #2 both have the Aa genotype. Therefore the probability that Individual #6 will be a carrier is 2/3 rd . In comparison Individual #7 is most certainly a carrier since one of his parents (individual #4 who has the genotype aa) has the disease. Therefore the probability that the child of individuals #6 and #7 will have the disease is 1/4 th . Combining all the probabilities together, the probability that the child will have the disease is 2/3 X 1/4 = 1/6th. 2. Consider the pedigree below showing the inheritance of two X-linked diseases, hemophilia A and hemophilia B . Hemophilia A is due to a lack of one clotting factor, and hemophilia B is due to a lack of

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