chem_430_skeleton4_Notes_fall2006

chem_430_skeleton4_Notes_fall2006 - skeleton 4 Hogan, Chem...

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skeleton 4 Hogan, Chem 130 Lecture notes The Citric Acid Cycle (Krebs cycle, TCA cycle) I. Review of glucose catabolism to this point. A. Glucose 2 pyruvate (Glycolysis) B. In the cell C. Fates of pyruvate 1. Anaerobic 2. Aerobic metabolism Before we discuss the 8 reactions of the TCA cycle, we first need to talk about the enzymatic reaction that converts the 3-carbon molecule, pyruvate to the 2-carbon compound, Acetyl CoA. I. Pyruvate dehydrogenase complex D. Example of a multi-enzyme complex E. Advantages 1
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skeleton 4 Hogan, Chem 130 Lecture notes F. Pyruvate dehydrogenase complex Reaction 1: Decarboxylation of pyruvate. Formation of a hydroxyethyl-TPP intermediate. Enzyme: (E1) Reaction 2: Enzyme: (E2) Hydroxyethyl attacks lipoamide S-S. TPP is eliminated. Reaction 3: E2 catalyzes a transesterification reaction in which the acetyl group from lipoamide is transferred to CoA Reaction 4 and 5: Enzyme: (E3) Transfer of 2 electrons and 2 protons to reduce S-S in E3. 2 electrons and 2 protons are then passed to FAD FADH 2 2
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skeleton 4 Hogan, Chem 130 Lecture notes II. The Citric Acid Cycle G. Circular pathway H. Central Area of metabolism I. Consists of 8 enzyme catalyzed reactions The 8 Reactions of the Citric Acid Cycle Reaction 1: Condensation of Acetyl-CoA with Oxaloacetate (OAA) Enzyme = citrate synthase Reaction 2: Converstion of citrate to isocitrate. Enzyme = aconitase Reaction 3: Converstion of isocitrate to α -ketoglutarate. Enzyme = Isocitrate dehydrogenase 3
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skeleton 4 Hogan, Chem 130 Lecture notes Reaction 4: Converstion of α -ketoglutarate to succinyl-CoA. Enzyme = -ketoglutarate dehydrogenase complex Reaction 5: Conversion of succinyl-CoA to succinate Enzyme = Succinyl-CoA synthetase (note that this enzyme is named for the reverse reaction). 4
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skeleton 4 Hogan, Chem 130 Lecture notes Reaction 6: Oxidation of succinate to fumarate Enzyme = Succinate dehydrogenase (a.k.a. Complex II) . Reaction 7: Hydration of fumarate to malate Enzyme = Fumarase Reaction 8: Oxidation of malate to oxaloacetate Enzyme = malate dehydrogenase 5
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skeleton 4 Hogan, Chem 130 Lecture notes Chapter 17: Electron transport and oxidative phosphorylation I. Intro and background A. Source of most of the energy for ATP synthesis comes from the oxidation of NADH B. Total reduced coenzymes from glycolysis and TCA: 1. Glycolysis:
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This note was uploaded on 03/14/2011 for the course CHEM 430H taught by Professor Hogan during the Spring '11 term at UNC.

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chem_430_skeleton4_Notes_fall2006 - skeleton 4 Hogan, Chem...

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