Solution Set 7_2011

Solution Set 7_2011 - Bioc100B Winter 2011 Rubin Problem...

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Bioc100B Winter 2011 Rubin Problem Set #7 It is not required that you turn this problem set in. See following pages for more practice problems for final! 1) Ligands that bind to and affect function of G-protein coupled receptors are often described as agonists, inverse agonists, or antagonists. Define each of these terms and find examples of physiological ligands or drug compounds that fit each category. What are the receptors that your examples bind and what are the functions of those receptors? If known, describe how each ligand interacts with its receptor. Examples are abundant. Here is one of each: An agonist is a molecule that binds to a receptor and increases its signaling response, i.e. it upregulates the signaling pathway. An example of an agonist is the opiate morphine, which binds to the μ - opioid receptor in the brain and gastrointestinal tract. The opioid receptor response in the brain results in analgesia (feeling “without pain”). While exact details of binding are unknown, it has been proposed that there are two
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This note was uploaded on 03/16/2011 for the course BIOC 100B taught by Professor Sethrubin during the Winter '10 term at UCSC.

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Solution Set 7_2011 - Bioc100B Winter 2011 Rubin Problem...

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