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Practice_Final _key_2011

Practice_Final _key_2011 - B iocl00B Winter 20ll Rubin 1...

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Biocl00B Winter 20ll Rubin 1) lmagine you have a metrod thatdetermines how much compound enteE a bacterial cell so that vou courd essenriarv measure uptarJ .aGs iffiortionartoh";;";;;;ih; ftmorane;. Youmeasure the bllorving rates for two cornpounds: a) la/hich compound "*"*j:- Tl1_tloust 11edj+"d difrrsion and which enrrers rhe cetl through passive diftrsion? Expnrn your ansner. [g pts] C-^1r...,oJ -b C(/tLo^+1*f"r / .... ".- \Ji-U /l S*L^&l .l *)f I F- tn) L^R$ +L ovel o")) ..'l- o? 4' ll {,sl* ;/ ;s ),At -H-l n onl,'> +1"1. rvu):otd )..il,t:,n. 0 o-nl,s )4*1\ f^ss:w ):il"s'^' l,r l/_ CB) Lr J.ft.,l,,... rJ*s ll-l Ve r;J\.r<- "'e tL f^le o{ &^frrvnJ
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Biocl00B Winter 20ll Rubin b) Suppose you determine that the compound that enters through mediated difrtsion is glutamine, and you leam that this bacGria has a channel that facilitates glutamine diffrrsion. You find that the diftrsion of both asparagine and homoglutamine (like glutamine but extra methylene in the sidechain) arenot enhances bythe channel. Discuss what struc{ural features of the channel and its mechanism of facilitating dift.rsion may explain the difierences in behavior of these molecules. [10 pts] .sl 6t^ 1,*nc 4v -C-c -o' ) l gQu It '- t c---t) \ rv$u A<^ ,r | 'il to fifN - C- O-c ) .JJ, I Czo I ,r4 l-..- rl" AOrlt u ff.vt !- 1! o' v t ) cHt '.
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  • Winter '10
  • SethRubin
  • Trigraph, lmagine ou havea, asparaginend homoglutamine glutamine, lmagine receptoryrosine inase, therapeuticn signalransduction. ptseach, ut extra features

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