2010-Endo-03sv - PSL200Y and PSL201Y Endocrine 3: Thyroid...

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PSL200Y and PSL201Y Endocrine 3: Thyroid hormones Lecture outline Anatomy of the thyroid gland hyroid hormones (T T Thyroid hormones (T 3 & T 4 ) Regulation Synthesis Function Thyroid hormone disorders Textbook reading Chp 6: 155 (3 rd 153) p ( ) Chp 21: 625-627 (3 rd 623-625)
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Recall: Endocrine glands Figure 6.1
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hyroid Gland Thyroid Gland Figure 6.8
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Recall: Hypothalamic/anterior pituitary hormones Figure 6.5 TRH=Thyrotropin Releasing Hormone TSH=Thyroid Stimulating Hormone TH=Thyroid Hormones T3, T4
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Regulation of thyroid hormone secretion Hypothalamus Regul a Thyrotropin releasing hormone (TRH) secretion tion Thyroid stimulating hormone (TSH) secretion Anterior pituitary Thyroid gland Long loop negative feedback Thyroid hormone secretion ~Figure 21.17 (3 rd Figure 6.7) Target cell response
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hyroid Gland: Microscopic view Thyroid Gland: Microscopic view Prod u Colloid contains: Thyroglobulin = protein – Precursor for thyroid ormones ction hormones – Contains tyrosine residues – Located in colloid nzymes Enzymes Iodine Figure 21.16 (3 rd Figure 21.13)
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Synthesis and secretion of thyroid yy hormones Figure 21.16 (3 rd Figure 21.13)
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Structure of thyroid hormones Thyroglobulin H0 H0 H0 H0 Figure from Silverthorn (2007) Human Physiology
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Steps in the synthesis of thyroid ormones TG hormones Direction of blood flow TG DIT MIT DIT DIT 1 Blood vessel Colloid Follicular cell Synthesis and secretion of thyroid hormones (b) Figure 21.16 (3 rd Figure 21.13)
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This note was uploaded on 03/17/2011 for the course PSL 200 taught by Professor Averback during the Fall '11 term at University of Toronto- Toronto.

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2010-Endo-03sv - PSL200Y and PSL201Y Endocrine 3: Thyroid...

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