005urinary system2010 lecture5

005urinary system2010 lecture5 - Renal Physiology: Lecture...

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Unformatted text preview: Renal Physiology: Lecture 5 Acid-Base Balance 2010-2011 Dr. L. Mavrogiannis MD PhD louie.mavrogiannis@utoronto.ca 7.35 -7.42 What are the sources of H+? PCO2 in arterial blood is 40mm Hg Protein in diet phosphoric and sulphuric acid Fat in diet Free fatty acids Exercise lactic acid Vomiting loss of H+ Diarrhea loss of HCO3- H HCO CO H O H CO 3 3 2 2 2 C.A. Defence of excess acid or base 1. Buffers (plasma and cells) 2. Kidneys 3. Lungs Defence of excess acid or base 1. Buffering system In the ECF it is primarily bicarbonate (24mM) In the ICF it is proteins (e.g. hemoglobin) Minimizes changes, works within seconds Mass action effect 3 2 3 CO H HCO H An example. Buffer will exhaust, and pH will change dramatically unless you are able to replenish the buffer. (pg 570, Chapter 18) 2 3 CO of handling lung HCO of handling renal pH Not an ideal buffer but, most important in...
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This note was uploaded on 03/17/2011 for the course PSL 200 taught by Professor Averback during the Fall '11 term at University of Toronto- Toronto.

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005urinary system2010 lecture5 - Renal Physiology: Lecture...

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