004Copy of The Urinary System2010 lecture4

004Copy of The Urinary System2010 lecture4 - Renal...

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Renal Physiology: Lecture 4 Fluid and Electrolyte balance 2010-2011 Dr. L. Mavrogiannis MD PhD [email protected]
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Daily stresses of volume and solute
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Short -term consequences of solute and water imbalances: osmolarity changes
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Short -term consequences of solute and water imbalances: volume changes • Interaction between the renal and cardiovascular system – Alterations in blood pressure (cardio lectures) • Baroreceptors –high pressure sensors – Changes in sympathetic tone • Cardiopulmonary baroreceptors- volume detectors – Naturetic peptides – Antidiurectic hormone (both discussed later)
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Long-term consequences of solute and water imbalances • Resetting Mean Arterial Pressure set-point – Set-point around which the baroreceptor reflexes operate is fixed by the kidneys not the brainstem vasomotor centre
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Blood pressure variations in normal and baroreceptor denervated dogs (This slide for interest only) Cowley et al 1973
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Response Response • Given the daily range of fluid and solute intake, the kidneys must be able to separate salt from water.
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However. .. • If the body is in osmotic equilibrium i.e., 300 mOsm/L, the urine could never be more or less concentrated than the surrounding body fluids. • How does the kidney have the ability to change the concentration of urine? N.B. Water is either reabsorbed or it is not, there is no secretion The Medullary Countercurrent Multiplier and regional specialization
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300 300 300 300 600 900 1200
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Hyposomotic to ECF
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This note was uploaded on 03/17/2011 for the course PSL 200 taught by Professor Averback during the Fall '11 term at University of Toronto.

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004Copy of The Urinary System2010 lecture4 - Renal...

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