membrane-dynamics

membrane-dynamics - Membrane Dynamics Membrane Cell...

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Membrane Dynamics Membrane Dynamics Cell membrane structures and functions Cell membrane structures and functions Membranes form fluid body compartments Membranes form fluid body compartments Membranes as barriers and gatekeepers Membranes as barriers and gatekeepers How products move across membranes How products move across membranes i.e., methods of transport i.e., methods of transport Chemical and electrical imbalances Chemical and electrical imbalances Membrane permeability and changes Membrane permeability and changes
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The Cell
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The Cell Membrane Fluid Mosaic Model Phospholipids Integral Proteins Peripheral Proteins Glycocalyx Glycoproteins MHC Glycolipids Cholesterol
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Cell Membrane Structure: Fluid Mosaic Model Cell Membrane Structure: Fluid Mosaic Model Thickness ~ 8nm PLs Cholesterol Proteins: peripheral (associated) or integral
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Phospholipids
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The Cell Phospholipids Hydrophilic Hydrophobic Amphipatic
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Passive Transport Passive Transport = Diffusion ( Def?) – 3 types: 1. simple diffusion 2. osmosis 3. facilitated diffusion (= mediated transport) Active Transport Active Transport Always protein-mediated 3 types: co-transport co-transport vesicular transport vesicular transport receptor mediated transport receptor mediated transport
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Movement across Membrane Movement across Membrane Membrane permeability varies for Membrane permeability varies for different different molecules molecules & & cell types cell types Two movement categories: Two movement categories: Passive Passive and and Active Active depends on??
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Fick’s law of Diffusion surface area x conc. gradient membrane resistance x membrane thickness rate of diffusion = depends on size and lipid-solubility of molecule and composition of lipid bilayer
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Membrane Spanning Protein Fig 5-5
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Cytoskeleton Proteins anchor membrane proteins
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Diffusion Process (Passive) Fig 5-5 Uses energy of concentration Uses energy of concentration gradient gradient Net movement until state of Net movement until state of equilibrium reached (no more equilibrium reached (no more conc. gradient) conc. gradient) Direct correlation to temperature Direct correlation to temperature (why?) (why?) Indirect correlation to molecule Indirect correlation to molecule size size Slower with increasing distance Slower with increasing distance Lipophilic molecules can difuse Lipophilic molecules can difuse through the phospholipid bilayer through the phospholipid bilayer
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Time for diffusion to progress to given distance ~ to distance squared
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membrane-dynamics - Membrane Dynamics Membrane Cell...

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