Week 4 Study Worksheet - Week 4 Study Worksheet 1. Contrast...

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Week 4 Study Worksheet 1. Contrast the “lock and key” model of enzyme-substrate interaction with the “induced fit” model. Lock and Key – In this early model, the enzyme molecule was regarded as a rigid structure with an active site that fits the substrate as a lock does a key. Reaction at the active site then converts molecules of substrate into molecules of products. Induced-fit model – According to this model, binding of a substrate molecule to the active site of an enzyme induces a conformational change in the enzyme molecule that positions the substrate into the enzyme. The transition state is stabilized. 2. Enzymes lower activation energy and speed up reactions. Describe several ways they can do this. Enzymes are essentially catalysts. They provide a perfect microenvironment by stabilizing the transition state and putting the molecules in close proximity. 3. When a reaction is catalyzed, how does the ΔG compare to when the same reaction is uncatalyzed? ΔG is the same. Enzymes do not affect ΔG.
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Week 4 Study Worksheet - Week 4 Study Worksheet 1. Contrast...

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