Lecture 09 - 020111

Lecture 09 - 020111 - Lecture Julian Schroeder I Nerve...

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1 Lecture Julian Schroeder I. Nerve Tissue Function and Organization II. Ion Gradients III. Resting Potential IV. Action Potential
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2 I. NERVE TISSUE Function & Organization A. CELL TYPES 1) Neurons Function: carry electrical signals 2) Glial Cells and Schwann Cells Function: support, electrical insulation Figure 48.8 Input Signals dendrites Synapse Ion Gradients: see overhead transparencies
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3 II. ION GRADIENTS Figure 48.10 Resting Potential: see: over head transparencies III. RESTING POTENTIAL Negatively charged proteins Chemical Force : K + flows out negative inside Electrical Force : opposite charges attract one another K + stops flowing out when: [chemical force] = [electrical force] Gradient (10x): equilibrium potential At 20 o C E K+ = -58 mV at room temperature at 37 o C E K+ -62 mV
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4 III. RESTING POTENTIAL | E K+ | ~ K + gradient (charge z = +1) E K+ = 58mV/(z) x log([K + ] out /[K + ] in ) E K+ = 58mV/(+1) x log(15mM/150mM) E K+ = 58mV x (-1) E K+ = -58mV (for 10-fold gradient) E K+ = 58mV x log(5mM/150mM) E K+ = -85mV (for 15-fold gradient) 5mM K + out 150mM K + in Video: resting potential
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