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lecture7(2) - Lecture 7 9.1 Major Modes of Regulation 9.2...

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9.1. Major Modes of Regulation 9.2. DNA Binding Proteins 9.3. Negative Control of Transcription: Repression and Induction 9.4 Positive Control of Transcription 9.5. Two-Component Regulatory Systems 9.7. Regulation of Chemotaxis Lecture 7 Lecture 7
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regulation regulation : : different conditions require different strategies changes in nutrients available sporulation permits specific response key cellular enzymes are constitutive but impractical to make every protein all the time excess proteins may be costly cellular activities can be regulated at multiple levels
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possible mechanisms of regulation: possible mechanisms of regulation: control expression control activity
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feedback inhibition: feedback inhibition: often encountered in biosynthetic pathways e.g. amino acid synthesis end product inhibition
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enzyme inhibition by allosteric effector: enzyme inhibition by allosteric effector: effector often pathway end product
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feedback inhibition, branched biosynthetic pathway:
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feedback inhibition of a common pathway: isozymes : catalyze same reaction but subject to different regulatory control
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enzyme modifications: enzyme modifications:
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