2018 10 08 with answer.docx - 201810\/8 10 1 You carried out the Ames test to analyze two chemicals A and B for its potential carcinogenicity To do the

2018 10 08 with answer.docx - 201810/8 10 1 You carried out...

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201810/8, 10 1. You carried out the Ames test to analyze two chemicals A and B for its potential carcinogenicity. To do the test, you used two strains of his - Salmonella typhimurium and  Strains and are designed to detect base substitution and frameshift mutations, respectively. After the test, you found that chemical A could generate revertants when only strain was used, and chemical B could not generate any revertants. When the chemicals A and B were incubated with rat liver extract before being treated to the bacteria, chemical B also could generate his + colonies with both and . Based on this statement, describe the nature of these two compounds. Because chemical A could induce the formation of revertants in only strain that has base substitution, chemical A can induce base substitution but not frame-shift mutation. Chemical B could generate revertants in neither strain nor , so chemical B is not mutagenic by itself. However, it became mutagenic by being treated with rat liver
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