Chapter 15 Notes

Chapter 15 Notes - Ingrid Shih BIO 1305-08 10 November 2010...

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Ingrid Shih BIO 1305-08 10 November 2010 Gene Mutation and Molecular Medicine Mutations Fairly common in DNA, however most are not noticeable Def: changes in the nucleotide sequence of DNA Somatic mutations o Not passed on to offspring Germ line mutations o Occur w/in gametes and can be passed on to offspring Phenotypic Effects o Silent mutation Occurs in non-coding DNA But may show in mRNA o Loss of function Mutation results in a nonfunctional or reduced function proteins In gametes- usually recessive trait o Gain of function A protein a new function Dominant trait in gametes Somatic cell: usually leads to cancer Conditional Mutations Conditional on some factor (i.e. temperature) Two categories at the molecular level Point mutation o Silent mutation o Nonsense mutation Only one amino acid translated; no proteins o Frame-shift mutation Bases could be added or removed All amino acids changed beyond the point of insertion
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This note was uploaded on 03/23/2011 for the course BIO 1305 taught by Professor Eldridge during the Fall '08 term at Baylor.

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Chapter 15 Notes - Ingrid Shih BIO 1305-08 10 November 2010...

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