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F08 LS1a Pset 8 final-1

F08 LS1a Pset 8 final-1 - Name TF Name 1 LS1a Fall 08...

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Unformatted text preview: Name: TF Name: 1 LS1a Fall 08 Problem Set #8 Due Tuesday 12/2 at noon in your TF’s drop box on the 2 nd floor of the Science Center (100 points total) 1. (32 points) The toxin produced by the bacterium Clostridium botulinum is a potent neurotoxin. When used in high doses, the toxin causes death through paralysis. However, at low doses the toxin can be used for cosmetic purposes or to treat overactive muscles. Botulinum Toxin (BTX) prevents neurons from being able to activate muscle contractions. BTX accomplishes this through proteolytic activity (by degrading specific proteins). a. One explanation is that BTX prevents the budding of neurotransmitter containing vesicles from the Golgi apparatus. If this explanation is correct, what class of proteins would BTX most likely target for degradation? Briefly explain. b. Another explanation is that BTX prevents the fusion of neurotransmitter- containing vesicles with the plasma membrane. If this explanation is correct, what class of proteins would BTX most likely target for degradation? Briefly explain. explain....
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F08 LS1a Pset 8 final-1 - Name TF Name 1 LS1a Fall 08...

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