F08 LS1a Pset 5keyst

F08 LS1a Pset 5keyst - Name TF Name LS1a Fall 08 Problem...

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Name: TF Name: 1 LS1a Fall 08 Problem Set #5 Due Monday 11/3 at noon in your TF’s drop box on the 2 nd floor of the Science Center All questions should be turned in. (100 points) 1. (46 points) Many proteins bind to DNA using alpha helices that bind to the major groove and recognize specific base sequences. The diagram below shows a region of a protein binding to the major groove of DNA. Two specific residues in the helix that form close interactions with specific bases in the DNA are highlighted. (a) Briefly explain why the major and minor grooves are of unequal widths. (8 points) The sugar groups are not located 180 degrees from one another so one groove (major groove) is wider than the other (minor groove). One of the interactions between the helix and the DNA above involves hydrogen-bonds between an arginine sidechain and a guanine base. The arginine sidechain is redrawn together with the guanine and cytosine bases on the next page.
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Name: TF Name: 2 (b) In the diagram below, draw in all hydrogen bonds between the guanine and
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F08 LS1a Pset 5keyst - Name TF Name LS1a Fall 08 Problem...

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