ANS18-10-L16-SALMON-GEN-ENG

ANS18-10-L16-SALMON-GEN-ENG - The case of the AquAdvantage...

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Alison Van Eenennaam, Ph.D. Cooperative Extension Specialist Animal Biotechnology and Genomics Department of Animal Science University of California, Davis http://animalscience.ucdavis.edu/animalbiotech/ ANS 18 11/3/2010 The case of the AquAdvantage salmon Alison Van Eenennaam , Ph.D., UC Davis
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Animal Biotechnology and Genomics Education ANS 18 11/3/2010 Proteins are the building blocks of life
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ANS 18 11/3/2010 Animal Biotechnology and Genomics Education What is a transgenic organism ? Transgenic organisms (GMOs) can be defined as those which have received sequences of DNA by artificial means, followed by integration of one or more of the novel sequences into their chromosomal DNA Maclean and Laight. 2000. Transgenic fish: an evaluation of the risks and benefits. Fish and Fisheries 1:146-172
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Animal Biotechnology and Genomics Education ANS 18 11/3/2010 Growth enhancement Freeze resistance and cold tolerance Salinity tolerance Disease resistance Metabolic modification Improved product for the consumer Sterility Fishpharming production of pharmacological proteins Current and potential applications of transgenic fish Maclean and Laight. 2000. Fish and Fisheries 1:146-172
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Alison Van Eenennaam , Ph.D., UC Davis What is the AquAdvantage salmon? ANS 18 11/3/2010
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Alison Van Eenennaam , Ph.D., UC Davis Same-age siblings one carrying a hemizygous copy of the transgene ANS 18 11/3/2010
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Alison Van Eenennaam , Ph.D., UC Davis Fish reach adult size in 16 to 18 months instead of 30 months ANS 18 11/3/2010
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Alison Van Eenennaam , Ph.D., UC Davis Retrieved from “AquAdvantage” image search on web ANS 18 11/3/2010
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Alison Van Eenennaam , Ph.D., UC Davis Retrieved from “AquAdvantage” image search on web Frankenfish ANS 18 11/3/2010
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Alison Van Eenennaam , Ph.D., UC Davis Retrieved from “AquAdvantage” image search on web ANS 18 11/3/2010
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Animal Biotechnology and Genomics Education ANS 18 11/3/2010 The procedure used to produce the fish is unnatural and therefore undesirable Transgenes could confer undesirable as well as desirable new properties on the fish Transgene incorporation could lead to other genetic problems (pleiotropic effects) Novel proteins could be allergens The fish, although not interbreeding, could be viewed as equivalent to an introduced alien species Fish might interbreed with the wild native fish and cause ecological harm Objections to transgenic fish Maclean and Laight. 2000. Fish and Fisheries 1:146-172
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What are the regulatory options for GE animals? 1. “Substantial Equivalence” approach 2. “Food Additive” approach 3. “New Animal Drug” approach Alison Van Eenennaam , Ph.D., UC Davis ANS 18 11/3/2010
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“Substantial Equivalence” approach Similar to approach taken with crops FDA could encourage developers to voluntarily consult with agency but no formal regulatory proceeding required If materially different (i.e. has toxin or allergen) then FDA can require additional approvals and labeling Developer accepts legal responsibility NO PUBLIC INPUT PEW 2003. Future Fish: Issues in Science and Regulation of Transgenic Fish Alison Van Eenennaam , Ph.D., UC Davis
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