NPB+112+11+Olfaction

NPB+112+11+Olfaction - • Mitral cells project to higher...

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Olfaction: March 8 th , 2011 I. Organization and anatomy II. Olfactory Receptor Neurons III.Olfacation Transduction Mechanisms IV.Central pathways
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Thuret et al., Nature Reviews Neuroscience 7, 628 643 (August 2006)
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ODOR G olf Adenyl cyclase cAMP ATP Na + Ca + Na + Ca + Cl Cl Ca + Na + Olfactory Signal Transduction ODOR G olf Adenyl cyclase cAMP ATP Na + Ca + Na + Ca + Cl Cl Ca + Na + P 1. Phosphorylation of GPCR = inhibition Adaptation to odors CAM Ca + 2. Calcium Calmodulin complex inhibits cAMP binding to channel
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Rinaldi, Andrea. EMBO Rep. 2007 July; 8(7): 629–633. Glomerulus = basic unit in odor map of olfactory bulb Each glomerulus receives input from olfactory receptor neurons expressing only one type of olfactory receptor
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Unformatted text preview: • Mitral cells project to higher order brain areas Kobayakawa et al., Nature 450, 503 ‐ 508(2007) “Olfactory Cortex” "Mice are naturally terrified of cats and usually panic or flee at the smell of one. But mice with certain nasal cells removed through genetic engineering didn't display any fear, the mice approached the cat, even snuggled up to it and played with it.” Ko Kobayakawa Kobayakawa et al., Nature 450, 503 ‐ 508(2007) Δ D mice have part of olfactory bulb destroyed, no longer avoid noxious/unpleasant/predator odorants No longer avoid predatory smells...
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NPB+112+11+Olfaction - • Mitral cells project to higher...

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