NPB+112+11+Olfaction+slides

NPB+112+11+Olfaction+slides - Glomerulus = basic unit in...

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Olfaction: March 8 th , 2011 I. Organization and anatomy II. Olfactory Receptor Neurons III.Olfacation Transduction Mechanisms IV.Central pathways
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Odorant Receptor Cell
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Thuret et al., Nature Reviews Neuroscience 7, 628-643 (August 2006) Richard Axel and Linda Buck. 2004 Nobel Prize in Physiology and Medicine Discovering odorant receptors and olfactory organization. •1,000 genes code for odorant receptor molecules •Each olfactory receptor cell possesses only one type of odorant receptor •Each receptor can detect a limited number of odorant substances Mitral cells
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ODOR G olf Adenyl cyclase cAMP ATP Na + Ca + Na + Ca + Cl - Cl - Ca + Na + Olfactory Signal Transduction
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ODOR G olf Adenyl cyclase cAMP ATP Na + Ca + Na + Ca + Cl - Cl - Ca + Na + P 1. Phosphorylation of GPCR = inhibition Adaptation to odors CAM Ca + 2. Calcium-Calmodulin complex inhibits cAMP binding to channel
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Rinaldi, Andrea. EMBO Rep. 2007 July; 8(7): 629–633.
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Unformatted text preview: Glomerulus = basic unit in odor map of olfactory bulb Each glomerulus receives input from olfactory receptor neurons expressing only one type of olfactory receptor Mitral cells project to higher order brain areas Kobayakawa et al., Nature 450, 503-508(2007) Olfactory Cortex "Mice are naturally terrified of cats and usually panic or flee at the smell of one. But mice with certain nasal cells removed through genetic engineering didn't display any fear, the mice approached the cat, even snuggled up to it and played with it. Ko Kobayakawa Kobayakawa et al., Nature 450, 503-508(2007) D mice b have part of olfactory bulb destroyed, no longer avoid noxious/unpleasant/predator odorants No longer avoid predatory smells...
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NPB+112+11+Olfaction+slides - Glomerulus = basic unit in...

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