Olfaction+Slide+Notes - NPB112,Winter2011...

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NPB 112, Winter 2011: 3/8/11 Olfaction, Chapter 15 (pages 363 365, 369 372, 375 381) I. Organization and Anatomy A. Nasal cavity: odorants enter through nose B. Olfactory epithelium: contains olfactory receptor cells, supporting cells, and stem cells C. Olfactory receptor cells (ORC): a. Cilia project into mucus membrane (responsible for odor detection) b. Strong negative current when odorants are pipetted onto them due to: i. Positive charge flowing into ORC (see Transduction Pathways) ii. Negative charge flowing out of ORC (see Transduction Pathways) D. Olfactory Bulb: part of brain (small in humans, much larger in other mammals and amphibians) a. Contain glomeruli which are: i. Axons of specific taste receptors from a single tastant ii. Dendrites of a mitral cell E. Mitral cells: project to higher brain areas (see below) II. Olfactory Receptor Cells/Neurons A. Richard Axel and Linda Buck 2004 Nobel Prize a. 1,000 genes each code for separate olfactory receptor b. Each olfactory receptor cell
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Olfaction+Slide+Notes - NPB112,Winter2011...

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