Olfaction+Slide+Notes

Olfaction+Slide+Notes - NPB112,Winter2011...

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NPB 112, Winter 2011: 3/8/11 Olfaction, Chapter 15 (pages 363 365, 369 372, 375 381) I. Organization and Anatomy A. Nasal cavity: odorants enter through nose B. Olfactory epithelium: contains olfactory receptor cells, supporting cells, and stem cells C. Olfactory receptor cells (ORC): a. Cilia project into mucus membrane (responsible for odor detection) b. Strong negative current when odorants are pipetted onto them due to: i. Positive charge flowing into ORC (see Transduction Pathways) ii. Negative charge flowing out of ORC (see Transduction Pathways) D. Olfactory Bulb: part of brain (small in humans, much larger in other mammals and amphibians) a. Contain glomeruli which are: i. Axons of specific taste receptors from a single tastant ii. Dendrites of a mitral cell E. Mitral cells: project to higher brain areas (see below) II. Olfactory Receptor Cells/Neurons A. Richard Axel and Linda Buck 2004 Nobel Prize a. 1,000 genes each code for separate olfactory receptor b. Each olfactory receptor cell single olfactory receptor c. Each olfactory receptor responds to a single odorant
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