Session 12 - Life Sci 2C03 Lecture 12 Session 12 Blood...

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Life Sci 2C03 – Lecture 12 Session 12 – Blood Brain Barrier (BBB) Introduction 1. Astrocytes facilitate quick vascular response to neuronal metabolic demands 2. Brain is only 2% of body weight 1. 20% of total Blood 2. 20% of total Oxygen 3. 20% of total glucose 1. One gram of brain shares about 200 cm 2 of its surface area with blood 1. the total length of blood vessels lining the cortex is about 400 miles 2. yet, WBC, RBC and most chemical substances in the blood CANNOT enter the brain 1. this is important for normal neuronal and synaptic function 2. metabolites of WBC and RBC are neurotoxic 1. Goldmann’s Classical Experiment (1913) 1. Trypan Blue injected in blood did not stain Brain of CSF 2. Trypan Blue injected in CSF stains Brain 3. There is a “impermeable Barrier” between Blood and CSF; Blood and Brain Components of BBB 1. Definition : a selective physicohemical barrier between blood and brain 2. Components
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Life Sci 2C03 – Lecture 12 1. endothelial cells 1. Tight junctions (TJ) between blood vessel endothelial cells – most imp component; TJ only seen in brain capillaries 1. Tight Junctions are made of specialized proteins – Occludins and Claudins 1. Occludins and Claudins are destroyed by – Trauma, epileptic seizures and AIDS virus 1. Destruction of Occludins and Caludins destroys BBB 2. basement membrane (BM) – an additional barrier that reinforces the BBB
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Session 12 - Life Sci 2C03 Lecture 12 Session 12 Blood...

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