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Unformatted text preview: Life Sci 2C03 – L13 Session 13 – Glia 1. Glial cells thought of as supportive cells at first 1. Now we know much more Glia: “glue cells” M icroglia : Neuroprotective 1. Trauma,hemmorage etc. leads to infiltration of brain by polymorphonuclear cells and other blood cells don’t want this 2. Breakdown products of these cells are very toxic to the brain 3. Function 1. Phagocytotic – process of microglia directly engulf these substances and offer neuroprotection 4. Microglia also release neurotrophic factors that are important in nerve cell repair (IMP!) 5. Microglia act as “ Local Police” 6. Time-lapse video imaging of a microglia engulfing a polymorphonuclear leucocyte (PMN) 1. The white dotted line indicates the trajectory of the PMN 2. By 19 mins , the PMN has already been engulfed 1. Hippocampal Slice Study 1. Slice exposed to: Life Sci 2C03 – L13 A. Oxygen-glucose-deprivat ion (OGD) 1. Significant nerve damage when removed B. OGD + Polymorphonuclear leucocyte (PMN) 1. Significant damage to neural t issue C. OGD + PMN + Microglia 1. Damage significantly reduced when M icroglia added 2. Neural death minimized due to microglia D. OGD + PMN + Macrophages 1. Addition of macrophages no significant reduction of damage 1. ONLY M ICROGLIA SHOWED...
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- Spring '11
- ife Sci 2C03, Ast rocyte