Session 15 - Life Sci 2C03 L15 Session 15 Growth Cones and...

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Life Sci 2C03 – L15 Session 15 – Growth Cones and Resting Membrane Potentials Growth Cones 1. Developing Visual Pathway 1. Fibres in eye cross and some remain on same side … why? 1. Active process that repel and attract certain fibres 1. Growth Cones 1. Attracted/repelled by particular molecules; grow extremely fast 2. Active terminal of a developing axon that seeks nerve/muscle/gland-targets 3. Has filopodia that actively explore due to cytoskeleton substances guided by molecular cues 1. Filopodia are finger-like processes containing actin that exhibit motility 2. The central core has microtubules that actively integrate and disintegrate with the actin to cause projection and withdrawal of filopodia 3. Interaction of receptors on the cone-membrane with various “guidance molecules” determines advancement or withdrawal of the filopodia 4. Intracellular signaling cascades are involved in both these processes 5. Asymmetric signaling causes turns in the cones 1. “Molecular Address” and topographic maps – Sperry’s Experiment
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Session 15 - Life Sci 2C03 L15 Session 15 Growth Cones and...

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