Session 17 - Session 17 Synaptic Transmission (cont)...

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Session 17 – Synaptic Transmission (cont…) Neurotransmitter Release 1. Criteria that define a neurotransmitter 1. Stored in presynaptic terminal 2. Action potential 3. Bind to postsynaptic receptor 1. Molecular basis of exocytosis during neurotransmitter release 1. Resting Neuron ” (Ca 2+ levels in the nerve terminal are relatively low); Vesicle Docking 1. SNARE proteins; 2 groups: 1. Vesicle : binds to target SNARE 2. Target : vesicle binds here 1. No Ca 2+ at all here 2. Docking process begins when little Ca 2+ is present 1. Activated State ” (increased levels of Ca 2+ in the nerve terminal) ; Vesicle Fusion and Exocytosis 1. Ca 2+ can come from synaptic terminal and can be released from organelles (mitochondria) 2. No Ca 2+ no docking 3. Vesicle must fuse w/ post synaptic terminal
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1) Prior to vesicular docking 2) Vesicular docking with the help of Ca++ and SNARE complex 3) High Calcium activates Synaptotagmin 4) Calcium-activated Synaptotagmin leading to vesicular fusion and exocytosis of
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Session 17 - Session 17 Synaptic Transmission (cont)...

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