Session 18 - Life Sci 2C03 L18 Session 18 Synaptic T...

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Unformatted text preview: Life Sci 2C03 L18 Session 18 Synaptic T ransmission 3 Neurotransmitter I nactivation 1. Neurotransmitter Reuptake ( Most Common) 1. taken back into pre synaptic terminal 2. Postsynaptic enzymatic inactivation (only seen with Acetylcholin e, Enzyme: Acetylcholinesterase) 1. Enzymes on postsynaptic neuron breaks down acetylcholine into acetate and choline Life Sci 2C03 L18 1. Local recycling of synaptic vesicles in presynaptic terminals 1. Horseradish peroxidase (HRP) (Marker) and electron microscopy 1. Stimulate pre-synaptic terminal briefly inject HRP marker HRP remains in cleft attaches to neurotransmitter vesicle in cleft (RIGHT) 1. Astrocyte clears excess glutamate 1. Neurotransmitters can be taken up by glial cells 1. What are autoreceptors? ***** 1. Specialized synaptic, regulatory-proteins bound to the pre and post synaptic nerve terminals; fine tuning of neurotransmitter activity 1. Presynaptic autoreceptor : regulate release and even synthesis of neurotransm itters 2. Postsynaptic autoreceotor : regulate surface expression of receptors by receptor-internalizat ion 1. Determ ines amount of receptors present on post-synaptic neuron; receptor internalized if too much neurotransm itters 1. Postsynaptic auto-receptor and Receptor-Internalizat ion 1. Drug Habituat ion 1. Neurotransm itters attach to receptors regulated by auto-receptors Life Sci 2C03 L18 2. Neurotransmitters along with receptor are internalized: Pathway 1 protein can be broken down by lysosome Pathway 2 re-insertion of recycled receptor 1. Cigarette Nicotine 1. Cell desensitized after full cigarette is done (receptor internalized)...
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Session 18 - Life Sci 2C03 L18 Session 18 Synaptic T...

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