Session 20 - Life Sci 2C03 L20 Session 20 Synaptic...

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Life Sci 2C03 – L20 Session 20 – Synaptic Plasticity and Neurogenesis Synaptic Plasticity 1. RECAP : NMDA receptor channel can only open during depolarization 2. “plasticity” = change 3. high-frequency stimulations cause strengthening of synapse /Long Term Potentiation (LTP) Low frequency stimulations cause weakening of synapses / Long Term Depression (LTD) 1. LTP and LTD 1. Coupling of LTP and LTD helps in pruning synapses during development as well as learning 2. LTP and LTD have been demonstrated in several areas of nervous system 3. In the hippocampus, LTP > 10Hz stimulation; LTD < 10Hz stimulation 4. Both may be mediated through NMDA and Ca 2+ signaling 1. LTP vs. LTP Spine Morphology Neocortical Neurons 1. LTP causes increase in spine size and neck-conductance, AMPA and NMDA receptor density 1. Neck is longer and slender 2. LTD has an opposite effect ; small plastic spine 1. Small synaptic terminal PSD – post synaptic density 1. Dendritic spine constantly changing its morphology 2. RECAP: Time-lapse imaging demonstrating changes in dendritic spines of hippocampus over minute-time scale following epileptic seizures
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This note was uploaded on 03/26/2011 for the course LIFESCI 2c03 taught by Professor Ullal during the Spring '11 term at McMaster University.

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Session 20 - Life Sci 2C03 L20 Session 20 Synaptic...

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