Lecture 4 - Biology 2A03 L4 ro when the systemLecture 4:...

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ero when the system reaches diffusive equilibrium or diffusion exists Biology 2A03 – L4 Lecture 4: Protein Activity (cont…), Transport Mechanisms I Metabolic Pathways One of the major roles of metabolic pathway is to convert the enrgy in food (stored as fuel) to ATP to power cellular functions ATP Production Metabolic pathways synthesize ATP through carbohydrates, lipids, proteins ATP Consumption (movement, membrane transport, molecular synthesis) ATP can be produced by: a) Substrate-level phosphorylation (occurs in absence of O 2 ) b) Kreb’s Cycle (TCA, citric acid cycle) c) Oxidative phosphorylation ( by definition uses O 2 in mitochondria) Goal : maintain ATP concentrations and keep it stable (homeostasis) Mitochondria Functions 1. “power house” of cell (generates most ATP) 2. Enzymes of Kreb’s Cycle in matrix 3. Electron transport chain on cristae of inner membrane 1. Ex. If oxygen taken out of room, the rate of ATP production is maintained by anaerobic production etc. and when fuel for this is gone (glucose) we die 2. Oxygen we breathe ends up in mitochondria 3. Enzymes of Kreb’s cycle are in matrix 4. Structure 1. Outer Membrane 1. Freely permeable to small molecules and ions (relatively non-selective) 1. Inner Membrane 1
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Biology 2A03 – L4 1. Impermeable to most small molecules and ions including H+ (protons) 2. Contains respiratory complexes (ETC) 3. ATP synthase F 0 F 1 4. Important because protons pumped into inner membrane space creating electrical gradient and travel through ATPase making ATP 1. Matrix 1. Contains the citric acid cycle enzymes (also called Kreb’s Cycle or TCA) 2. Fat oxidizing enzyme B-oxidization 3. Pyruvate Dehydrogenase (PDH) 1. Helps determine whether glucose is used by oxygen or converted to lactate 1. Transport Mechanisms
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This note was uploaded on 03/26/2011 for the course BIOLOGY 2a03 taught by Professor Nurse during the Spring '10 term at McMaster University.

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Lecture 4 - Biology 2A03 L4 ro when the systemLecture 4:...

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