Lecture 6 - Biology 2A03 L6 Lecture 6 Signal Transduction...

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Biology 2A03 – L6 Lecture 6 – Signal Transduction Signal Transduction Pathways 1. Detect intercellular messengers and convert them into a biologically meaningful response inside cell 2. 4 features of signal transduction pathways: 1) Specificity 1. the signal molecule fits in its receptor while others do not 2. can also have messenger bind to multiple receptors with different affinities 3. ex. Specificity for a particular hormone (epinepherin) 2) Amplification 1. 1 receptor binding can lead to 1,000,000 products inside cell 3) Desensitization/ Adaptation 1. Feedback shuts off receptor or removes it 2. Cellular response desensitizes that messenger for its ligand, receptors become accustomed to the messenger more ligand needed to illicit a response from receptor 4) Integration 1. Outcome the result of integration of both receptor inputs 2. Multiple inputs integrated into a signal Receptors 1. The magnitude of a cell’s response depends on: 1) The messenger’s concentration 2) The # of receptors present 3) Affinity of receptor for messenger
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Lecture 6 - Biology 2A03 L6 Lecture 6 Signal Transduction...

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