Lec20 - MCB 102 Professor Markus Pauly 03/07/11 Lecture 20...

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MCB 102 Professor Markus Pauly 03/07/11 Lecture 20 ASUC Lecture Notes Online is the only authorized note-taking service at UC Berkeley. Do not share, copy, or illegally distribute (electronically or otherwise) these notes. Our student-run program depends on your individual subscription for its continued existence. These notes are copyrighted by the University of California and are for your personal use only. D O N O T C O P Y Sharing or copying these notes is illegal and could end note taking for this course. ANNOUNCEMENTS There will be NO office hours this Friday. Thursday office hours will be the same. I will make up for this by holding extra office hours during the week of the midterm. LECTURE Last week we finished talking about the TCA or citric acid cycle. You should know what comes in and what goes out of the cycle as well as all the structures in between except for the aconitase reaction. You should also know all the enzymes involved in the cycle. Today we will be discussing fatty acid metabolism. Fatty acids are stored in adipocytes as triacylglycerols (1 glycerol and 3 fatty acids). The fatty acids in a triacylglycerol may be saturated (no double bonds) or unsaturated (one or more double bonds). You should know the structure of palmitic acid (16-C saturated fatty acid) as its degradation is considered in this lecture. As fats are ingested, they move to the small intestines, where the gall bladder releases bile salts to emulsify fat droplets and lipase cleaves off the fatty acids from the glycerol. Fatty acids are then transported by chylomicrons to other tissues in the body (myocytes and adipocytes). Chylomicrons are large lipoprotein particles that allow fats to move within the bloodstream. These lipid bodies can be very-low-density lipoproteins (VLDL or “bad” fats) or high-density lipoproteins (HDL or “good” fats). Under low blood glucose sugar, the body needs to
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Lec20 - MCB 102 Professor Markus Pauly 03/07/11 Lecture 20...

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