Lecture_13rr_Q___Autoreg+Pacing

Lecture_13rr_Q___Autoreg+Pacing - IB 132 Human Physiology...

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Unformatted text preview: IB 132: Human Physiology Lecture 13: Control of Cardiac Output and Regional Blood Flow Widmaier, Raff & Strang Chapter 12 Professor George A. Brooks Professor Daniela Kaufer “I’ve got rhythm.” Today’s Outline • Frank-Starling Relationship • Fick Relationship • Control of Regional Blood Flow • Cardiac Pacing a. Lower than Sean’s b. The same as Sean’s c. Higher than Sean’s d. Never changes e. Choices (a) and (d) Bailey Gross’ (3 yr) Heart Resting Heart Rate is a. Splanchnic contraction to increase arterial O 2 content b. Increase total cardiac output c. Shunt blood to the active area d. Increase the tissue arterial-venous oxygen difference e. Choices (b) and (c) To increase tissue O 2 delivery we humans can increase tissue blood flow by: Myocardial Regulation • Extrinsic, e.g., influences of norepinephrine and epinephrine. • Intrinsic, e.g., the Frank- Starling or Length-Tension Relationship Autonomic Innervation of The Heart Intrinsic Myocardial Regulation • Frank-Starling or Length-Tension Relationship Which Determines That The Strength of Contraction and Myocardial Length (EDV) • EDV is Related to Venous Return or “Preload.” Myocardial Function • Is Positively Affected by Venous Return or “Preload.” • Is Negatively Affected by Systolic Blood Pressure or “Afterload.” Operating Range for the Heart Normal Fig 9-21m (EDV) To increase the heart’s stroke volume: fill it more fully with blood. The increased stretch of the ventricle will align its actin and myosin in a more optimal pattern of overlap. Fig. 12-24 Ventricular Function “Starling” Curve “Positive Inotropy” Inotropy Increases the Ejection Fraction Fig. 12-25 Fig. 12-65 in HF Why for the failing heart is some fluid retention helpful, but more retention a major problem? What is the effect of CHD on Ejection Fraction? in HF Excessive Diastolic Filling If Weakened Myocardium Puts the Person on the Downslope of the Length- Tension Relationship in HF The “Fick Relationship” The Integration of Pulmonary Minute Ventilation, Cardiovascular Dynamics, and Oxygen Transport Use Adolph Fick (1829-1901) Würzburg The Fick Relationship of Oxygen Transport Use and Pulmonary Minute Ventilation VO 2 = Q (a-v)O 2 Q = VO 2 /(a-v)O 2 The Fick Relationship of Oxygen Transport Use VO 2 = Q (a-v)O 2 VO 2 = Flow ( O 2 Extraction) VO 2 = f V s (a-v)O 2 VO 2 = ( Heart Rate) (Stroke Volume) (O 2 Extraction) The Fick Relationship of Oxygen Transport Use The Fick Relationship of Oxygen Transport Use The Fick Relationship of Oxygen Transport Use VO 2 = Q (a-v)O 2 Q = VO 2 /(a-v)O 2 where: VO 2 is Pulmonary O 2 Consumption a is arterial O...
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This note was uploaded on 03/26/2011 for the course PSYCH 166A taught by Professor Peng during the Spring '11 term at Berkeley.

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Lecture_13rr_Q___Autoreg+Pacing - IB 132 Human Physiology...

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