Lecture_17r_Renal_Regulation

Lecture_17r_Renal_Regulation - Readings...

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1 Lecture 17: Renal Regulation 2 Readings • For Today: Chapter 14 B,C,D 3 Outline: Renal Regulation 1. Regulation of water balance 2. Regulation of Na + 3. Regulation of K + 4. Regulation of acid/base balance 4 Fluid Balance • Extracellular fluid serves as the intermediary between cells and the extracellular environment. • Plasma is the only fluid that can be acted on directly to control its volume and composition. • Because of free exchange across capillary walls, ECF volume and composition are regulated when plasma volume and composition are. 5 Control of Fluid Balance • Two factors are regulated to maintain fluid balance: – ECF osmolarity • Important to prevent swelling or shrinking of cells • Control of water balance is of primary importance – ECF volume • Important to regulate blood pressure • Control of salt balance is of primary importance 6 Control of Water Balance is of primary importance in regulating ECF osmolarity • Daily water input and output are well balanced. Two factors can be controlled: – Thirst influences the amount of fluid ingested – The kidneys can adjust how much water is excreted as urine • Water reabsorption is regulated in the medullary collecting ducts – Recall that 2/3 of the water that was filtered is reabsorbed in the proximal tubule, without regulation
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2 7 Vasopressin modulates water reabsorption in the medullary collecting ducts Figure 14-15 By making the medullary CD more permeable to water, vasopressin causes more water to be reabsorbed 8 What signal should be sensed in a feedback control system regulating H 2 O reabsorption? A. Plasma osmolarity B. Concentration of H 2 O in plasma C. Concentration of H 2 O in urine D. Urine osmolarity E. All of the above 9 What signal should be sensed in a feedback control system regulating H 2 O reabsorption? A. Plasma osmolarity B. Concentration of H 2 O in plasma C. Concentration of H 2 O in urine D. Urine osmolarity E. All of the above 10 Hypothalamic Osmoreceptors • Increased osmolarity (too little H 2 O) is sensed by osmoreceptors in the hypothalamus • These osmoreceptors signal thirst and cause release of vasopressin.
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Lecture_17r_Renal_Regulation - Readings...

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