Exam1-09 - Name: January 30, 2009 ETX 103A Short concise...

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Name: January 30, 2009 ETX 103A Exam I Short concise answers recommended 100 points total 1. Suppose o-toluidine (see below) causes bladder cancer in the average dog (and human) and acts by the same mechanism as benzidine and other aromatic amine bladder carcinogens. a. Show a phase 1 reaction followed by a phase 2 reaction likely to be responsible for this outcome. (8 pts) b. Give a likely explanation (words or reactions) why bladder is the carcinogenic target. (8 pts) 2. Using only phase II reactions, show four different types of conjugates of the compound below as illustrated in class. (12 pts) H 2 N-CH 2 -CH-CH=CH-CHO | OH 3. A nitrosamine compound metabolized by α -hydroxylation yielded the stable carbon-containing compounds shown below. By inspection, what was the structure of the original nitrosamine? (8 pts) HOCH 2 -CHO CH 3 -CH-CHO HOCH 2 -CH 2 OH CH 3 -CH-CH 2 OH | | CH 3 CH 3
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4. For toxicity testing, most people believe the rat is a good model for the mouse. However, large differences in sensitivity toward the two agents below are evident in the kidney between these species.
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Exam1-09 - Name: January 30, 2009 ETX 103A Short concise...

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