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Exam2-09 - Name ETX 103A Short concise answers recommended...

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Name: February 27, 2009 ETX 103A Exam II Short concise answers recommended 100 points total 1. An ETX student learns that our average annual dietary intake of polybromodiphenylether (PBDE) flame retardants is 500 μ g and that the half life of elimination is three years. a. Assuming first order elimination kinetics, what is the average human body burden? (5 pts) b. If a person on a PBDE-free diet started eating a normal diet (as above), how soon would he reach 99% of his final body burden? (5 pts) c. Suppose when the maximal body burden is reached, his plasma level of PBDE is 6 μ g/liter. (6 pts) i. What is the volume of distribution of PBDE? ii. How do you interpret this result? 2. The venom of mamba snakes contains (i) a peptide that blocks acetylcholinesterase activity and (ii) an antagonist of axonal voltage gated potassium channels. a. Briefly explain how each component acts as a neurotoxin. (12 pts) i. Peptide AChE blocker ii. Potassium channel antagonist b. Do these two venom components reinforce each other’s action, or do they act in opposition? Explain. (4 pts)
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