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Exam3-09 - Name ETX 103A Short concise answers recommended...

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Name: March 20, 2009 ETX 103A Exam III Short concise answers recommended 200 points total 1. Chlorine gas was a highly feared chemical warfare agent in World War I. a. Give a reaction of Cl 2 with water and indicate products accounting for its deleterious effect in the lung. (5 pts) b. Explain why mixing bleach with acidic cleansers (e.g., containing HCl or acetic acid) can be dangerous for individuals cleaning at home or in institutions. (4 pts) c. Explain (words and/or equations) why mixing bleach with basic cleansers containing ammonia is dangerous for individuals cleaning at home or in institutions. (5 pts) 2. Dr. U. R. Theyer tests the potential new pharmaceutical Lucregen for teratogenicity in the rat (0.2 kg). Simulating average human exposure, he keeps the plasma concentration between 10 and 40 ng/ml starting at day 12 of pregnancy (total gestation time 21 days). The Vd of Lucregen is 1 liter/kg, and it has a half life of 6 hr in the blood. Show your calculations. (18 pts) a. Propose a good loading dose for Lucregen in the rat. b. Propose a subsequent dosing schedule that minimizes the frequency of doses. c. Suppose no birth defects are detectable in the rat offspring. Give two good reasons we cannot conclude Lucregen is non-teratogenic in humans. (i) (ii)
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3. The viral oncogene v-src in Rous sarcoma virus is derived from the cellular proto-oncogene c-src. In cells, this proto-oncogene ordinarily is inactivated by the kinase Csk and is activated by the phosphatase Ptp as indicated in part b below. a. What is the difference between an oncogene and a proto-oncogene? (6 pts) b. Which is more likely to be a proto-oncogene, Csk or Ptp? Explain. (8 pts) Csk c-Src c -Src-P (active)
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