Xm1 - Name: January 29, 2010 ETX 103A Exam I Short concise...

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N a m e : January 29, 2010 ETX 103A Exam I Short concise answers recommended 100 points total 1. Like benzene, naphthalene (shown below) can be metabolized by dioxygenase in micro- organisms and by mono-oxygenase (cytochrome P450) in us. (20 pts) a. For each reaction, give a stable phase 1 product of naphthalene. Dioxygenase Mono-oxygenase c. Show an unstable intermediate in the mono-oxygenase reaction above and two reactions with the intermediate (studied in class) that result in detoxification. Unstable intermediate Detoxification products 2. When treated for hypertension with the pharmaceutical hydralazine (shown below), two brothers (A and B) of the same size and weight are given the same dose. Although the brothers’ environments are identical, the therapeutic effect of a given dose is much more pronounced and lasts much longer in brother B than in brother A. (12 pts) a. Give a likely explanation why the brothers differ in response (see part b below). b.
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This note was uploaded on 03/27/2011 for the course ETX 103A taught by Professor Etx during the Winter '06 term at UC Davis.

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Xm1 - Name: January 29, 2010 ETX 103A Exam I Short concise...

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