Oncogenes+Discussion+Notes

Oncogenes+Discussion+Notes - Oncogenes - Review Questions...

Info iconThis preview shows pages 1–3. Sign up to view the full content.

View Full Document Right Arrow Icon
Oncogenes - Review Questions Question 1: Give 3 types of evidence that cancer occurs though a multistep process. Syllabus: Oncogenes page 6 1. For most types of cancer, incidence increases sharply with age. If cancer were caused by a single mutation, and this mutation had an equal chance of occurring any time, the incidence would be independent of age. Instead, the increase with age is consistent with the slow accumulation of numerous random mutations in a single line of cells. 2. Tumor Progression: The stepwise process by which an initial mildly abnormal cell gradually evolves into a full-blown cancer. Hyperplasia (increase in cell number) and /or dysplasia (disordered growth -- changes in size, shape, etc.) Carcinoma in situ - a preinvasive neoplasm. Dysplastic changes are significant and involve the entire thickness of the epithelium. Malignant tumor - Characterized by aggressive growth, invasion and destruction of surrounding tissue, and ability to metastasize (spread). Some malignant tumors also show anaplasia meaning that they are composed of undifferentiated cells. An example from epithelium:
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Oncogenes - Review Questions Question 1: Give 3 types of evidence that cancer occurs though a multistep process. Syllabus: Oncogenes page 6 3. As tumors progress towards malignancy, they exhibit accumulating DNA damage. Every human cancer that has been analyzed reveals multiple genetic alterations involving activation of several oncogenes and loss of two or more tumor suppressor genes (i.e. “hits”). Each “hit” represents a step in
Background image of page 2
Image of page 3
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 03/27/2011 for the course ETX 103A taught by Professor Etx during the Winter '06 term at UC Davis.

Page1 / 4

Oncogenes+Discussion+Notes - Oncogenes - Review Questions...

This preview shows document pages 1 - 3. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online