RQ8 - Name Key Due Review Questions Neurotoxicology 1...

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Name: Key Due: Review Questions - Neurotoxicology 1. Distinguish between ligand-gated (transmitter receptor) and voltage-gated (signal conductance) channels. Ligand-gated . An action potential is initiated at a postsynaptic cell membrane by chemical information from the presynaptic cell. This information consists of low molecular weight transmitters, which bind to specific receptors on the post-synaptic membrane. These receptors are ion channels that are opened by binding ligand. Voltage-gated . Transmission of an electrical impulse along an axon depends upon the ion channels there. These open in response to the changing internal voltage to which they are subject as the impulse approaches. Their opening in an orderly fashion propagates the impulse. 2. a. What are the basic steps in synaptic transmission by acetylcholine? An action potential at an axon endplate opens voltage-gated ion channels which permit flux of Ca ++ into the cytoplasm. The Ca ++ influx permits fusion of acetylcholine (AcCh) granules with the cell membrane at the synaptic cleft.
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