Tobacco+Disscussion+Notes

Tobacco+Disscussion+Notes - Tobacco - Review Questions 1....

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Tobacco -- Review Questions 1. What are the major types of evidence that smoking is harmful? Explain how they are comple- mentary. I. Epidemiologic Evidence: A. Strength of the association (relative risk) B. Dose-response relationship c. Temporal relationship D. Consistency between different studies
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Tobacco -- Review Questions Question 1 -- continued II. Animal experiments with tobacco smoke and mechanistic studies on disease progression Chemical constituents of the particulate phase of smoke are carcinogenic.: PAHs, nitrosamines, arylam- ines, and many others. Chemical constituents of the gas phase of smoke also show carcinogenic and other toxic effects: nitro- samines (carcinogens); cyanide, formaldehyde, acetaldehyde (ciliatoxic). Tobacco tar (particulate matter) shows carcinogenic effects in the mouse skin cancer bioassay. Experiments utilizing the dog lung helped provide evidence for the important role of elastase in producing emphysema. III. Animal experiments with chemical constituents of tobacco smoke The toxicity/carcinogenicity of the many chemical constituents in tobacco smoke indicate the danger, while the animal studies confirm the biological basis for disease resulting from exposure to tobacco smoke. The epidemiological studies demonstrate the effects on humans of tobacco use.
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This note was uploaded on 03/27/2011 for the course ETX 103A taught by Professor Etx during the Winter '06 term at UC Davis.

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Tobacco+Disscussion+Notes - Tobacco - Review Questions 1....

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