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2010 Bio 317 Lecture 5

2010 Bio 317 Lecture 5 - BIO 317 Lecture 5 Prof William...

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1 Prof. William Collins Office: 534 Life Sciences Building Office Hours: Mondays, 4:00 – 5:00 PM or by appointment Recommended Reading: Matthews, Chapter 7 BIO 317: Lecture 5 What Determines the Threshold Voltage for the Action Potential? g K E m E K ( ) g Na E m E Na ( ) = i K i Na When E m is at resting potential, K + and Na + currents are in balance. Assume that g K and g Na are not voltage dependent. What happens when E m is depolarized 15 mV from -70 mV to -55 mV? g K E m E K ( ) g Na E m E Na ( ) > i K i Na i K would increase in amplitude because the driving force would increase. i Na would decrease in amplitude because the driving force would decrease. Since i K > - i Na , K + current is the dominant influence and E m will repolarize to the resting potential, -70 mV.
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2 What Determines the Threshold Voltage for the Action Potential? Assume that g K and g Na ARE voltage dependent. What happens when E m is depolarized 15 mV from -70 mV to -55 mV? g K E m E K ( ) g Na E m E Na ( ) > ? < In reality, both g K and g Na are voltage dependent. Depolarization g Na (fast) and g K (slow).
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