2010 Bio 317 Lecture 6

2010 Bio 317 Lecture 6 - BIO 317: Lecture 6 Prof. William...

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1 Prof. William Collins OfFce: 534 Life Sciences Building OfFce Hours: Mondays, 4:00 – 5:00 PM or by appointment Recommended Reading: Handout#1 - Diseases of Muscle Na + Channels BIO 317: Lecture 6 Subfamilies of K + Channel Genes ±rom: Ion Channels of Excitable Membranes by B. Hille
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2 Correlating Na + Channel Structure and Function α -subunit: • is composed of about 20,000 amino acid residues with • 4 homologous repeats (I - IV) • each repeat contains 6 transmembrane segments (S1 - S6) • S4 segments contain charged residues and serve as voltage sensor From: Ion Channels and Disease by F. Ashcroft
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3 Correlating Na + Channel Structure and Function • Tetrodotoxin (TTX) binds to the outer mouth of the Na + channel, plugging the pore. • Therefore, point mutations in Na + channel protein that disrupt TTX action should de±ne the outer mouth of the pore • Same approach can be used with local anesthetics to de±ne the inner mouth of pore.
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This note was uploaded on 03/28/2011 for the course BIO 317 taught by Professor Simonhalegoua during the Fall '08 term at SUNY Stony Brook.

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2010 Bio 317 Lecture 6 - BIO 317: Lecture 6 Prof. William...

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