2010 Bio 317 Lecture 7

2010 Bio 317 Lecture 7 - BIO 317 Lecture 7 Prof Arianna...

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Prof. Arianna Maffei Office: 548 Life Sciences Building Office Hours: Tuesdays, 11:30 AM - 12:30 PM or by appointment Recommended Reading: Matthews - chapter 5 BIO 317: Lecture 7
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Galvani & bioelectricity (1786)
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Knee-Jerk Reflex NMJ is Model synapse
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Intercellular transmission of signals 3 components: 1- Presynaptic terminal 2- Postsynaptic cell 3- Apposition space
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Chemical Synaptic Transmission animation
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Neuromuscular Junction (NMJ) • Neurotransmitter is Acetylcholine (ACh) • When ACh binds to receptor, channels open -> depolarization called, “end plate potential” (EPP) • A the NMJ, each EPP is usually very large and produces an AP in the muscle cell and contraction “one-for-one” synapse
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Summary of Presynaptic Events • AP arrives in synaptic terminal • Produces depolarization of synaptic terminal • Voltage-dependent Ca ++ channels open • Ca ++ enters synaptic terminal • Ca ++ binds to calcium sensor molecules associated with synaptic vesicles • Synaptic vesicles fuse with synaptic membrane • Contents of synaptic vesicles ( neurotransmitter ) released into ECF directly across from target cell ( synaptic cleft ) -> local release
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Voltage-Gated Ca ++ Channels in Presynaptic Terminal • Depolarization opens Ca ++ channels high-voltage activated (HVA) fast, inactivating P/Q-type (Ca v N-type (Ca v 2.2) • Ca ++ enters from ECF [Ca ++ ] o 1 mM [Ca ++ ] i 0.1 μM E Ca +116 mV • Triggers exocytosis of synaptic vesicles containing neurotransmitter
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Ca ++ Control of Transmitter Release From: Ion Channels of Excitable Membranes by Bertil Hille Fluorescence from Ca ++ indicator, fura 2, increases in presynaptic terminal during Action Potential
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Transmitter release antagonized by [Mg ++ ] o Slope of lines in log-log plot 4, indicates that probability of transmitter release increases as the 4th power of [Ca ++ ] o Turbocurarine antagonizes Ach receptors, keeps EPP small From: Ion Channels of Excitable Membranes by Bertil Hille
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This note was uploaded on 03/28/2011 for the course BIO 317 taught by Professor Simonhalegoua during the Fall '08 term at SUNY Stony Brook.

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2010 Bio 317 Lecture 7 - BIO 317 Lecture 7 Prof Arianna...

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